Application

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected TDP-43 in human cerebellum, pancreas, and thalamus tissues.

Detect TDP-43 using this Anti-TDP-43 Antibody, clone DB9 validated for use in western blotting & IHC.

General description

TAR DNA-binding protein 43 (TDP-43) belongs to the hnRNP protein family and plays an important role in transcription, pre-mRNA splicing, mRNA stability and mRNA transport. It is involved in splicing of the apolipoprotein A-II and cystic fibrosis transmembrane gene. This protein is highly expressed in the pancreas, placenta, lung, genital tract and spleen. Mutations in TDP-43 have been associated with amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson′s disease and Alzheimer′s disease.

Immunogen

The antibody was raised against an immunogen consisting of His-tagged recombinant protein corresponding to amino acid residues 208-414 of human TDP-43.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Format: Purified

Quality

Evaluated by Western Blotting in SH-SY-5Y cell lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected TDP-43 in 10 µg of SH-SY-5Y cell lysate.

Target description

~43 kDa observed